Parkinson's disease - can the prion mechanism explain its onset in intestines?
In the last decade, there is more and more talk and evidence that Parkinson's disease (PD) is a prion-like disorder and may begin in the gut.
The prion-like mechanism of neurodegeneration assumes that the spread of the protein's pathological forms takes place in several stages.
In PD, the alpha-synuclein's alpha-helical structure changes to a β-sheet structure, which tends to aggregate and spread. It is assumed that the initiating factor may be intestinal dysbiosis.