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PTFarm Poznań


Parkinson's disease - can the prion mechanism explain its onset in intestines?

In the last decade, there is more and more talk and evidence that Parkinson's disease (PD) is a prion-like disorder and may begin in the gut.

The prion-like mechanism of neurodegeneration assumes that the spread of the protein's pathological forms takes place in several stages.
In PD, the alpha-synuclein's alpha-helical structure changes to a β-sheet structure, which tends to aggregate and spread. It is assumed that the initiating factor may be intestinal dysbiosis.

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